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Updated: Feb 15, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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uPAR 缺乏引发TGFβ1介导的纤维化重塑在心脏周血管类微环境中

Yulia Goltseva1, Zoya Tsokolaeva2,3, Irina Beloglazova2

  • 1National Medical Research Centre of Cardiology named after academician E.I. Chazov, Moscow, 121552, Russian Federation. YDgoltseva@cardio.ru.

Stem cell research & therapy
|February 14, 2026
PubMed
概括

泌尿酸酶等离子素激活器受体 (uPAR) 的损失通过破坏周围血管微环境并放大TGFβ1信号,使心脏纤维化恶化. 这突出了UPAR作为纤维性心脏病的潜在治疗点.

关键词:
三维细胞培养的3D细胞培养心脏球是什么?心脏球是什么?纤维细胞细胞.纤维化 纤维化 纤维化心灵 心灵 心灵 心灵 心灵 心灵周周血管微环境球形球形是指一个球形状的球体.在TGFβ1中.乌帕尔 (UPAR) 地区泌尿酸酶受体是什么意思

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