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Updated: Feb 15, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
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微结质BDNF/TrkB信号介导的KCC2功能障碍加剧早期中风后发作易感性

Jing Zhou1,2, Benjamin H Wang1, Jiangning Yu1

  • 1Department of Neurosurgery and Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute of Biological Science, Zhongshan Hospital, Fudan University, Shanghai, China.

CNS neuroscience & therapeutics
|February 14, 2026
PubMed
概括

微质衍生的BDNF/TrkB信号损害了KCC2功能,增加了中风后发作的风险. 抑制这种途径或增强KCC2为中风后提供了一个新的治疗策略.

关键词:
这就是为什么BDNF是BDNF.这就是为什么TrkBB.化物常态稳定 化物常态稳定缺血性中风 中风微质细胞中的微质细胞化共运输体 2 化共运输体发作 发作 这些

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