患有全身性硬化症的女性患者的第二到第四位数比率 (2D:4D):产前雄激素暴露的证据
Ramazan Fazil Akkoc1, Ahmet Karatas2, Burak Oz2
1Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Turkey.
概括
女性全身性硬化症 (SSc) 患者的第二到第四位数比率较低 (2D:4D),表明产前安卓激素暴露较高. 这表明产前荷尔蒙环境可能会影响SSc易感性.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性硬化症 (SSc) 主要影响女性,这表明其发病的原因是荷尔蒙因素.
- 第二到第四数字的比率 (2D:4D) 是产前雄激素暴露的生物标志物,并与自身免疫性疾病有关.
研究的目的:
- 为了研究女性SSc患者和健康对照者之间的2D:4D比率的差异.
- 探索产前荷尔蒙环境在SSc易感性中的潜在作用.
主要方法:
- 一项病例控制研究,涉及33名女性SSc患者和30名健康女性对照.
- 双边测量第二和第四位数的长度,使用数字校准器计算2D:4D比.
- 使用Welch的t测试和Mann-Whitney U测试进行统计分析来比较组.
主要成果:
- 与对照组相比,SSc患者的双边2D:4D比率明显较低 (p < 0.001).
- 较低的比率归因于较长的第四位数字,这表明产前雄激素暴露率升高.
- 效应大小很大 (科恩d > 2.8).
结论:
- 女性SSc患者的2D:4D比率明显较低,这意味着产前丸激素暴露率更高.
- 这些发现支持这样一个假设:产前荷尔蒙环境可能会导致SSc.的自身免疫性疾病易感性.
相关概念视频
The Evidence for Evolution
48.4K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Infertility in Females
4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
4.9K
Poisson's Ratio
1.4K
Poisson's ratio is a material property that indicates their stress response. It explains the connection between the elongation or compression a material undergoes in the direction of an applied force and the contraction or expansion it experiences perpendicular to that force. When a slender bar is loaded axially, it stretches in the direction of the force and contracts laterally. Poisson's ratio is the negative ratio of this lateral contraction to the axial elongation. The negative sign...
1.4K
Odds Ratio
1.9K
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
1.9K
External Female Genitals
36.1K
The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more...
36.1K
Disorders of the Female Reproductive System
4.5K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.5K


