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在糖尿病模型中,Psidium Guajava叶片提取物的抗糖尿病和抗高脂效应
Gunesh Kumar1,2, Ikram Din Ujjan3,4, Nasreen Qazi1,2
1Department of Pharmacology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 14, 2026
概括
在糖尿病子中,Psidium guajava的乙醇叶提取物显示出适度的血糖降低和脂质资料的显著改善. 更高的剂量也可以防止脏和肝脏受损.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢研究研究 代谢研究
背景情况:
- 瓜 (Psidium guajava) 是一种具有潜在治疗功能的植物.
- 糖尿病是一种代谢障碍,其特征是高血糖.
- 艾洛克桑是一种用于在实验模型中诱导糖尿病的化学剂.
研究的目的:
- 为了研究乙醇性Psidium瓜叶提取物的剂量依赖作用.
- 评估阿洛克桑诱导的糖尿病子对糖尿病和脂质特征的影响.
主要方法:
- 一项实验研究涉及48只被分成六组的雄.
- 使用阿洛克桑单水合物 (100 mg/kg) 诱导糖尿病.
- 治疗组在28天内接受了不同剂量的P. guajava提取物 (100,150,200毫克/公斤) 或glibenclamide.
主要成果:
- 200mg/kg剂量的P. guajava提取物显示出显著的低血糖效应 (p = 0.002).
- 在200mg/kg的剂量下观察到脂质特征的显著改善:降低了LDL,甘油三,总胆固醇,增加了HDL.
- 150-200毫克/公斤的剂量提供了预防糖尿病引起的和肝损伤的保护.
结论:
- 果 (Psidium guajava) 叶片提取物具有抗高脂和适度的抗高血糖特性.
- 提取物对糖尿病子的脏和肝脏产生保护作用.
- 更高的剂量 (150-200毫克/公斤) 与显著的治疗益处有关.
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