在肝细胞癌中,循环miR-1233结合双CT参数的诊断值
1Radiology Department, Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Wenling, China.
Journal of clinical ultrasound : JCU
|February 14, 2026
概括
血清miR-1233在肝细胞癌 (HCC) 患者中升高,有助于早期检测. 将miR-1233与双源CT扫描相结合,可显著提高HCC的诊断准确性.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 医疗成像医学成像
背景情况:
- 早期的肝细胞癌 (HCC) 往往会逃避检测.
- 异常的微RNA-1233 (miR-1233) 表达在各种癌症中被发现,但其在HCC中的作用尚不清楚.
研究的目的:
- 为了评估miR-1233表达在HCC患者.
- 评估miR-1233用于HCC检测的诊断性能.
主要方法:
- 对100例良性肝瘤病例和120例HCC病例进行前性研究.
- 通过qRT-PCR和双源CT成像量化血清miR-1233.
- 对miR-1233与AFP和DCP的相关性分析;用于诊断性能的ROC曲线分析.
主要成果:
- 在HCC患者中,血清miR-1233的调控显著上升.
- miR-1233表达与AFP和DCP正相关.
- 单独miR-1233的AUC为0.821;与双CT参数相结合,AUC达到0.944,灵敏度和特异性>90%.
结论:
- 血清miR-1233是HCC的一个潜在生物标志物.
- 将miR-1233与双源CT结合起来,与单独使用这两种方法相比,对HCC的诊断效率更高.
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