肝胰脂肪沉积:对心脏代谢多病症和心脏功能障碍的影响
Li-You Lian1,2,3, Tianyi Xia4, Zhong-Wei Chen5
1MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
概括
与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 和胰腺脂肪酸症 (PS) 共同显著增加心脏代谢多病风险. 这种双器官肥胖症也推动了心脏重塑,突显了这些疾病的相互联系.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 和胰腺脂肪酸症 (PS) 与心脏代谢问题有关.
- 对于MASLD和PS对长期心脏代谢多病症 (CMM) 和心脏重塑的综合影响尚不清楚.
研究的目的:
- 调查PS和MASLD组织学严重程度之间的关联.
- 评估单器官与双器官肥胖症 (MASLD和PS) 患者中CMM和心脏变化的长期风险.
- 探索潜在的分子途径,涉及到双器官肥胖症.
主要方法:
- 在活检验证的队列中对PS和MASLD组织学的横截面分析.
- 英国生物银行队列分析 (n=16,408) 评估发生的CMM和心磁共振 (CMR) 在中位数5.6年的随访期间的发现.
- 探索性蛋白质基因分析,以确定分子通路.
主要成果:
- PS与更严重的MASLD组织学相关,包括肥胖症,炎症和纤维化.
- 同时存在的MASLD和PS增加了新发性CMM的风险 (HR=2.013).
- 双器官肥胖症与左心室质量增加和心脏功能受损有关,蛋白质组分析显示了升调的溶酶体和葡萄糖氨基糖降解途径.
结论:
- 胰腺肥胖症与更严重的肝病组织学有关.
- 同时服用MASLD和PS显著增加心脏代谢多病症和心脏重塑的风险.
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