测试检测Candida auris从特有地区的医院内转移后的殖民化,一个前性的观察性研究
Laura Mezzogori1,2, Martina Bavastro1,2, Laura Magnasco2
1Department of Health Sciences, University of Genoa, Genoa, Italy.
Mycoses
|February 14, 2026
概括
在转移之前,单个阴性Candida auris查抹布不足以排除殖民. 在转移后两周内重复查对于检测殖民和预防传播至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 医院流行病学 医院流行病学
背景情况:
- 国际指导方针缺乏明确的建议,用于管理从Candida auris特有病房转移到非特有病房的患者.
- 最佳的时间和查抽样的数量,以排除殖民仍然不清楚.
研究的目的:
- 评估转移后查方案在检测未被殖民的患者中Candida auris殖民化的有效性.
- 确定最佳的查策略,以防止Candida auris.水平传播.
主要方法:
- 从Candida auris流行性ICU转移到非流行病病房的成年患者的前性观察研究.
- 在转移后的0-1,2-3天,以及每周一次,对部/部扫描进行实时PCR查.
- 被认为足够查的患者,如果在转移后4周内≥2个拭子呈阴性,则被视为足够查.
主要成果:
- 在440名未被殖民的患者中,有208人得到了充分的查,其中16.3%的检测结果在移植后呈阳性Candida auris.
- 7.1%的患者有负面的转移前拭子检测结果,后来呈阳性.
- 刚刚检测到的转移后殖民化的患者中,有11.8%的患者出现了Candida auris候选症.
结论:
- 一个单一的负面转移前查抽样不足以排除Candida auris殖民.
- 在移植后的前两周内重复查对于准确的检测至关重要.
- 有效的查协议对于防止在医疗机构中进一步传播Candida auris至关重要.
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