在英国生物银行参与者中,白天户外时间与生物年龄加速之间的关联
Jia-Dong Ning1, Pan-Pan Zhu1, Xiaofeng Ma1
1State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
International journal of environmental health research
|February 14, 2026
概括
每天在户外度过适当的时间,特别是夏天2小时,冬天1小时,与生物衰老的减缓有关. 超过这个最佳时间可能会加速衰老,而更短的时间也会对衰老标志物产生负面影响.
科学领域:
- 老年学是一门学科.
- 环境健康 环境健康
- 生物统计学 生物统计学
背景情况:
- 生物年龄 (BA) 加速是衰老的标志物,受生活方式因素的影响.
- 白天户外时间 (TOD) 是影响健康和衰老的潜在可修改因素.
研究的目的:
- 调查白天户外时间 (TOD) 与生物衰老加速之间的关联.
- 为了确定TOD的最佳持续时间,以减轻生物衰老加速.
主要方法:
- 使用克莱梅拉-杜巴尔方法BA (KDM-BA) 和表型年龄 (PhenoAge) 余量与时间年龄计算生物年龄加速.
- 采用了通用添加模型来评估TOD与夏季和冬季BA加速的关联.
主要成果:
- 为了最大限度地减少KDM-BA加速的最佳TOD是夏季每天2小时,冬季每天1小时.
- 对于PhenoAge加速的最佳TOD比KDM-BA.大约长了一个小时.
- 当TOD超过最佳水平时,BA指标都显示加速;PhenoAge加速在两个季节都下降,TOD低于最佳水平,而KDM-BA仅在冬季显示负相关性.
结论:
- 适当的白天户外活动时间在促进健康衰老方面发挥着至关重要的作用.
- TOD的特定持续时间与生物衰老加速的减少有关,因季节而异.
- 了解最佳的TOD可以为健康衰老的公共卫生策略提供信息.
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