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Antibody Structure01:10

Antibody Structure

65.8K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.8K
Antigen Presenting Cells01:22

Antigen Presenting Cells

3.4K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.4K
Specific Heat01:16

Specific Heat

67.8K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.8K
Antibody Actions01:26

Antibody Actions

3.0K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
3.0K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.7K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.7K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.4K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.4K

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  1. 首页
  2. Asd:抗原特异性抗体数据库.
  1. 首页
  2. Asd:抗原特异性抗体数据库.

相关实验视频

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.9K

ASD:抗原特异性抗体数据库.

Arkadiusz Czerwiński1, Paweł Dudzic1, Konrad Wójtowicz1

  • 1R&D Department, NaturalAntibody, Szczecin, Poland.

mAbs
|February 14, 2026

在PubMed 上查看摘要

概括
此摘要是机器生成的。

研究人员创建了抗原特异性抗体数据库 (ASD),以应对治疗性抗体开发的挑战. 这种全面的资源有助于使用聚合数据预测抗体-抗原相互作用和结合亲和力.

关键词:
抗体的设计设计.结合性亲和力是一种结合性亲和力.生物信息学是一种生物信息学.计算免疫学计算免疫学数据库就是数据库.发现药物的发现.

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Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies
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Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies

Published on: January 26, 2019

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

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相关实验视频

Antigenic Liposomes for Generation of Disease-specific Antibodies
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Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

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Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies
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Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies

Published on: January 26, 2019

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

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科学领域:

  • 生物化学 生物化学
  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.

背景情况:

  • 治疗抗体的计算建模面临着重大挑战,主要是由于有限和稀缺的数据.
  • 预测抗体-抗原相互作用和结合亲和力对于抗体开发至关重要,但由于数据稀缺而受到阻碍.

研究的目的:

  • 开发一个全面的抗体-抗原相互作用数据库,以支持计算模型的开发.
  • 来自各种公共来源的抗体-抗原相互作用数据的汇总和标准化.

主要方法:

  • 从15个不同的来源收集了抗体-抗原相互作用数据.
  • 对所有聚合数据的标准化格式和注释.
  • 集成元数据包括UniProt/PDB标识符,目标名称和实验条件.

主要成果:

  • 创建了抗原特异性抗体数据库 (ASD),其中包含1,097,946个独特的抗体-抗原相互作用和9575个独特的抗原.
  • 该ASD包括各种亲和度,定性约束数据和广泛的元数据.
  • 该数据库为开发和验证抗体研究的计算模型提供了基础.

结论:

  • 抗原特异性抗体数据库 (ASD) 是一个有价值的,公开可用的资源,用于抗体研究.
  • ASD促进了计算模型的开发,用于预测抗体-抗原结合亲和力.
  • 这一综合数据集促进了进一步的数据生成和治疗抗体开发的进步.