在质瘤放射治疗后,YTHDF1基因多态和认知功能障碍之间的相关性
Huanfeng Zhu1, Xiyun Shi1,2, Dan Zong1
1Department of Radiation Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, China.
The International journal of neuroscience
|February 14, 2026
概括
质瘤放射治疗后YTHDF1过度表达与认知功能障碍有关. 在YTHDF1中的rs6090311 G基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因
科学领域:
- 神经瘤学神经瘤学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 质瘤是最常见的原发性恶性脑瘤.
- YTH N6-甲基氨酸RNA结合蛋白1 (YTHDF1) 在质瘤治疗反应中起着至关重要的作用.
- 了解影响治疗副作用的遗传因素,如认知功能障碍至关重要.
研究的目的:
- 为了研究YTHDF1单核酸多态 (SNPs) 与质瘤放射治疗后认知功能障碍之间的关联.
- 探索YTHDF1遗传变异作为预测治疗结果的生物标志物的潜力.
主要方法:
- 在放射治疗前和放射治疗后3个月内研究了323名质瘤患者的队列.
- 使用RT-qPCR量化YTHDF1mRNA的表达.
- 四个YTHDF1SNP被基因定型,并使用多变量逻辑回归分析了它们与认知功能障碍的关联.
主要成果:
- 在患有认知功能障碍 (CD组) 的患者中观察到YTHDF1mRNA表达升高.
- YTHDF1 SNP rs6090311显示了CD和非CD组之间基因型和等位基因频率的显著差异.
- 携带rs6090311 G等位基因的携带者在放射治疗后显著降低患有认知功能障碍的风险 (OR = 0.319).
结论:
- 过度表达YTHDF1与质瘤放射治疗后的认知功能障碍有关.
- YTHDF1的rs6090311 G等位基因可以作为一种保护性遗传标记物,用于防止质瘤患者在放射治疗后的认知功能障碍.
相关概念视频
02:20Correlations
36.6K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.6K
01:27Correlation and Causation
43.0K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
01:09Correlation
15.2K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.2K
01:05Single Nucleotide Polymorphisms-SNPs
18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
755
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
755