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Updated: Feb 15, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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尼托胺艾姆斯数据审查和方法开发:美国FDA/HESI研讨会的记录

Aisar Atrakchi1, Raechel Puglisi2, Joel Bercu3

  • 1US Food and Drug Administration/Center for Drug Evaluation and Research, Silver Spring, MD 20993.

Mutagenesis
|February 14, 2026
PubMed
概括

对药物中N-尼托拉胺 (NA) 突变致病性的担忧导致了一场研讨会,优化艾姆斯测试. 关键的结论集中在改善NA杂质检测和药品安全风险评估上.

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