在军事卫生系统中评估药物基因组处方数据
Rachel Zigler1, Austin Pagani2,3,4, Mark Haigney4,5
1Augustana-Sanford Genetic Counseling Program, Sioux Falls, SD 57197, United States.
Military medicine
|February 14, 2026
概括
军事卫生系统 (MHS) 中的预防性药物基因组 (PGx) 测试可以减少不良药物事件并提高准备. 许多服用PGx相关药物的MHS受益者可能具有非正常的新陈代谢,增加风险.
科学领域:
- 药物基因组学 药物基因组学
- 临床药理学 临床药理学
- 军人卫生保健 军人卫生保健
背景情况:
- 药物基因组测试 (PGx) 通常是反应性的,发生在药物不良事件 (ADEs) 后.
- 预防性PGx方法可以减少可预防的与毒品有关的住院治疗,并提高军事准备.
- 在军事卫生系统 (MHS) 内的预防性PGx测试的影响上存在有限的研究.
研究的目的:
- 估计预防性PGx测试在MHS中的潜在影响.
- 分析PGx相关药物的MHS处方数据和人口频率数据.
- 为了确定可能经历非正常药物代谢的受益人.
主要方法:
- 使用FY21 MHS处方数据进行了回顾性横截面研究.
- 包括临床药物遗传学实施联盟 (CPIC) A,A/B和B级别的药物.
- 基于生物地理群体的等位基和代谢器频率估计的非正常代谢.
主要成果:
- 分析了83种PGx相关药物的800多万份处方.
- 大约15% (120万) 的处方是针对现役和预备役军人的.
- 预计多达632,974名MHS受益者服用奥梅普拉的CYP2C19代谢异常.
结论:
- 尽管有关药物的处方广泛,但PGx测试在MHS中未得到充分利用.
- 相当数量的MHS受益者可能具有非正常的新陈代谢,增加ADE风险.
- 在MHS中实施预防性PGx测试可以减少ADEs,改善治疗结果,并提高服务人员的准备能力.
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