基于扩散张力成像 (DTI) 的自闭症儿童语言大脑区域网络的拓性质研究
Lili Zhang1, Miaoyan Wang2, Yunshu Jiang3
1Department of Child Health Care, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, 214000, Jiangsu Province, China. zlljxf@126.com.
Journal of autism and developmental disorders
|February 14, 2026
概括
患有自闭症谱系障碍 (ASD) 和全球发育迟缓 (GDD) 的儿童表现出不同的大脑网络结构. 特定大脑区域的连接性增加与ASD中较差的语言技能有关,这表明了独特的组织差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 计算精神病学是一种计算精神病学.
背景情况:
- 自闭症谱系障碍 (ASD) 和全球发育迟缓 (GDD) 是影响语言的神经发育的疾病.
- 在这些条件下理解语言的神经支对于有针对性的干预至关重要.
研究的目的:
- 为了比较ASD与GDD儿童的语言网络拓.
- 在这些群体中调查网络属性与语言功能之间的关联.
主要方法:
- 扩散张力成像 (DTI) 用于在65名ASD儿童和51名GDD儿童中绘制结构性大脑网络.
- 图形理论分析量化了语言相关网络中的节点指标.
- 层次回归模型检查了结构-功能关系的群组调节.
主要成果:
- 患有自闭症儿童的理解能力较低,但表达性语言得分与GDD儿童相比较.
- 自闭症组在右侧中旋 (MTG-R) 中表现出更高程度的中心性.
- 在ASD中,MTG-R和直角旋 (ANG-R) 连接/效率与语言表现负相关,根据诊断进行调节.
结论:
- 在语言网络中,ASD和GDD具有不同的局部拓特性.
- 结构组织中的疾病特异性差异,特别是MTG-R和ANG-R中增加的节点连接性,与ASD中较差的语言结果有关.
- 这项研究提供了网络层面的证据,证明在ASD和GDD之间的语言障碍中,大脑组织存在差异.
相关概念视频
01:10Higher Mental Functions of the Brain: Language
3.9K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
3.9K
01:24Inertia Tensor
1.2K
The concept of the inertia tensor is employed to depict the mass distribution and rotational inertia of a solid or rigid object. This tensor is expressed through a three-by-three matrix. Each component within this matrix corresponds to varying moments of inertia about specific axes.
The diagonal components of the inertia tensor matrix represent the moments of inertia concerning the principal axes of the object. These primary axes are defined as the axes where the object experiences the least...
The diagonal components of the inertia tensor matrix represent the moments of inertia concerning the principal axes of the object. These primary axes are defined as the axes where the object experiences the least...
1.2K
01:20Anatomy of the Brain: Major Regions
10.8K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
10.8K
01:12Diffusion
222.3K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
222.3K
01:16Language
924
Language is a unique communication system that uses words and systematic rules to organize and transmit information. Unlike other forms of communication, which may involve postures, movements, odors, or vocalizations, language relies on symbols and grammar. This makes human communication distinct from that of other species, who also communicate but do not use language in the same way humans do.
Corballis and Suddendorf (2007) and Tomasello and Rakoczy (2003) highlight the role of language in...
Corballis and Suddendorf (2007) and Tomasello and Rakoczy (2003) highlight the role of language in...
924
01:19Autism Spectrum Disorder
1.3K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.3K