戈米辛A和甲福明的联合治疗通过调节糖尿病大鼠模型中的AGE/RAGE通路来减轻糖尿病病和心血管功能障碍

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S P Ramya Ranjan Nayak¹, Pratik Pohokar¹, M Valan Arasu²

¹Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, 603203, India.

Molecular and cellular biochemistry

|February 14, 2026

概括

在糖尿病模型中,戈米辛A与甲福明相结合显示有望保护脏和心脏. 这种组合改善了血糖控制和减少炎症,为糖尿病并发症提供了潜在的辅助疗法.

科学领域:

药理学药理学是指药理学的学科.
腎臟病學 (nephrology) 是一種醫學專業.
心脏病学心脏病学

背景情况:

糖尿病病 (DN) 是2型糖尿病 (T2DM) 的严重并发症,通常与心血管疾病 (CVD) 和慢性病 (CKD) 一起发生.
目前对DN和CVD的治疗方法有局限性,并且可能导致不良影响.

研究的目的:

在糖尿病模型中评估Gomisin A单独和与甲福明一起的和心脏保护作用.
研究Gomisin A作为营养药辅助疗法的协同作用潜力.

主要方法:

给一个糖尿病模型注射戈米辛A (20毫克/千克) 和甲胺.
评估血糖控制,功能标志物 (血清肌素,尿素,),炎症标志物 (LDH,MDA) 和特定路径调制 (AGE/RAGE,NF-κB,TGF-β).
对心脏保护作用的评估,包括心肌缩和缩.

主要成果:

与单独使用戈米辛A相比,组合的戈米辛A和甲福明显著改善了血糖控制和β细胞完整性.
该组合预防了缩,减少了炎症,并调节了AGE/RAGE通路,降低了NF-κB和TGF-β的表达.
观察到显著的心脏保护作用,包括抑制心肌缩和心肌缩.

结论:

戈米辛A和甲福明在缓解糖尿病病和心血管疾病进展方面表现出协同作用.
戈米辛A显示出作为常规抗糖尿病治疗的辅助营养药的潜力,用于管理DN和CVD.

关键词:

心血管疾病是什么心血管疾病糖尿病脏病糖尿病脏病在这里,Gomisin和Gomisin是非常重要的.甲胺是一种甲胺.营养学辅助剂营养学辅助剂

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