定向PICO框架和在假牙系统审查中没有支持的结论:方法论分析
Geoffrey A Thompson1, Mohamed Elshewy1, Ahmed Zaher1
1Department of Restorative Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA.
概括
假牙系统审查中的方法选择可能会导致偏见的结论. 中立的框架和明确的结果差异化是牙科研究中可靠的证据综合的关键.
科学领域:
- 牙科研究 牙科研究
- 基于证据的牙科.
- 牙修复 牙修复 牙修复 牙修复 牙修复
背景情况:
- 系统性审查对于基于证据的假牙至关重要.
- 审查中的方法决定可以影响他们的结论.
- 了解这些影响对于准确解释研究结果至关重要.
研究的目的:
- 分析问题框架,代用结果和解释方法如何影响假牙系统审查中的结论.
- 通过有限,异质或间接证据来检查审查.
- 确定影响审查结果的模式.
主要方法:
- 用PICO (患者/问题,干预,比较,结果) 或专注的临床问题分析了八项牙套系统审查.
- 评估问题框架中立性,代孕与临床结果的处理以及异质性管理.
- 与柯克伦审查对解释的比例性和中立性进行比较.
主要成果:
- 所有审查的假牙系统审查都显示了由框架,证据类型或异质性影响的解释.
- 定向性的问题框架往往导致定向性的结论.
- 依赖代理或体外结果经常导致外推的临床建议.
结论:
- 定向框架,代用结果和证据限制似乎影响了假牙系统审查中的结论.
- 中立的框架,明确的结果差异化和透明的异质性管理可以改善未来的证据综合.
- 建议加强结论与证据确定性之间的协调.
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