证据中的地理差异 调查在慢性鼻炎中使用生物药物的证据
Itai Margulis1, Mohd Afiq Mohd Slim1,2,3, Ethan C Sommer4
1Division of Otolaryngology-Head & Neck Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
概括
生物药物对慢性鼻炎 (CRS) 是有前途的,但大多数研究来自美国和欧洲. 需要在非洲,亚洲和拉丁美洲等代表性不足的地区进行进一步的研究,以更好地报告种族/种族.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 临床药理学 临床药理学
背景情况:
- 慢性鼻炎 (CRS) 治疗格局正在随着生物疗法的发展而变化.
- 对于CRS生物制剂的临床试验数据的地理和人口差异尚不清楚.
研究的目的:
- 系统地审查和分析CRS生物剂研究中种群的多样性和代表性.
- 确定CRS生物制剂的全球文献中的地理差异和报告差距.
主要方法:
- 按照PRISMA指南进行系统审查,分析2006-2023年的研究和2006-2025年的RCT/RW研究.
- 数据提取包括患者的人口统计 (国家,种族/族裔),作者归属,生物类型和资金.
- 分析的重点是地理代表性,作者的人类发展指数 (HDI) 和种族/种族披露.
主要成果:
- 包括169项研究;杜皮卢马布是研究最多的生物药物.
- 美国和欧洲主导研究来源和作者归属.
- 只有11.2%的研究报告了患者的种族/种族,非洲,拉丁美洲和亚洲的数据有限.
结论:
- 虽然生物药物对CRS有效,但目前的证据严重倾向于北美和欧洲人口.
- 来自非洲,拉丁美洲和亚洲的代表人数显著不足,种族/种族报告不足.
- 未来的研究必须优先考虑多样化人群的纳入,以确保在CRS中获得生物疗法的公平和可概括的发现.
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