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Updated: Feb 16, 2026

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells
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单细胞多原子分析突出了NKX2.2-CLEC16A/内体通路在人类胰腺分化和功能中的重要作用

Guo Chen1, Xiaojie Ma1, Liling Jiang1

  • 1Life Sciences Institute, The Second Affiliated Hospital and School of Medicine, The MOE Key Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Zhejiang University, Hangzhou 310058, Zhejiang, China.

Cell reports
|February 14, 2026
PubMed
概括

研究人员特征了一种可扩展的胰腺原始体 (ePP) 系统,揭示了控制细胞命运和小岛功能的基因网络. 他们还开发了1型糖尿病的干细胞模型,确定了潜在的治疗点.

关键词:
在 CLEC16A 中,CP:细胞生物学 细胞生物学CP:干细胞研究.在 NKX2.2 中使用.糖尿病 糖尿病患者 糖尿病患者这是内体路径.可扩展的胰腺原始体基因监管网络 基因监管网络胰腺小岛的分化

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