病原体效应器通过准TCP14,这是时钟和防御的双重调节器,从而解除昼夜免疫交叉通话
Yu Wang1, Jiayue Wu1, Xuan Cui1
1College of Life Sciences, Capital Normal University, Beijing 100048, China; Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement, Beijing 100048, China.
Cell reports
|February 14, 2026
概括
病原体通过向转录因子TCP14,一个关键的昼夜免疫整合器来利用植物免疫枢纽. 这种破坏破坏了受时间限制的植物防御,揭示了宿主节律的脆弱性.
科学领域:
- 植物免疫力 植物免疫力
- 循环生物学的日间生物.
- 分子植物病原体相互作用
背景情况:
- 病原体向重要的植物宿主蛋白质,称为免疫枢纽,以克服防御.
- 特定宿主蛋白成为目标的进化原因尚未完全理解.
研究的目的:
- 调查转录因子TCP14作为昼夜节律和植物免疫之间的潜在联系的作用.
- 阐明病原体可能破坏植物防御时间的机制.
主要方法:
- 利用时间过程RNA测序 (RNA-seq) 和植物遗传分析.
- 研究了植物因素和病原体作用因子之间的蛋白质-蛋白质相互作用.
- 检查了时钟和防御基因的转录调节.
主要成果:
- TCP14充当昼夜免疫整合剂,其水平由时钟组件CCA1和ZTL节律控制.
- TCP14直接调节时钟基因的表达,并影响节律性基因表达,阴囊细胞生长和防御反应.
- 一种病原体效应剂,HaRxL21,与TCP14相互作用,抑制植物防御基因,破坏时间关闭的免疫力.
结论:
- TCP14作为一个关键的结合点,将昼夜定时与植物的防御优先级相结合.
- 病原体可以破坏这种慢性免疫连接,破坏宿主节奏并促进感染.
- 了解这种机制可以了解植物防御策略和病原体毒性战术.
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