复合赛马格卢提德和蒂尔泽帕提德产品使用独特配方,但有效性和安全性基本上是未知的
Jordyn Belcourt1, Amy Sapowadia1, C Michael White1
1Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA.
The Annals of pharmacotherapy
|February 14, 2026
概括
合成的西马格卢提德和蒂尔泽帕提德产品正在成为FDA批准药物的替代品. 然而,许多缺乏安全性和有效性的证据,添加了有疑问的营养素或其他成分.
科学领域:
- 制药科学 制药科学
- 药理学 药理学是指药理学的学科.
- 药物复杂化药物复杂化
背景情况:
- 创新的赛马格卢提德和提泽帕提德短缺问题已经得到解决,使复合药房能够提供独特的产品.
- 独特的复合产品可能具有改变的注射途径,剂量或额外的成分.
研究的目的:
- 为了识别和表征复合的西马格卢提德和蒂尔泽帕提德产品.
- 将这些产品与现有的FDA批准的配方进行比较.
主要方法:
- 从2025年2月3日到2025年3月20日,搜索化合物网站,使用诸如"化合物黄胺"和"化合物铁泽胺"等术语.
- 与商业选择相比,具有不同强度,使用途径或配方的产品.
主要成果:
- 确定了33种独特的复合性西马格卢提德和/或蒂尔泽帕提德产品.
- 48%的药物含有额外的成分,如蓝,甘氨酸,尼胺,多酸盐或丹塞.
- 单一成分产品中常见的是下舌或口服可分解片剂配方;关于储存和使用后的日期的信息有限.
结论:
- 添加营养物质或多库沙酸盐到化合物西马格卢提德/蒂尔泽帕提德的理由很少.
- 虽然Ondansetron有理由,但缺乏其皮下使用的证据.
- 新型下舌或ODT配方的安全性和有效性仍未确定,引发了人们对其作为FDA批准药物的替代品的受欢迎程度的担忧.
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