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重新审视自然循环的冷胚胎移植:一个系统的审查和元分析

Murat Erden^1,2, Sezcan Mumusoglu³, Esra Uyanik^1,4

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.

Human reproduction update

|February 14, 2026

概括

自然周期冷胚胎移植 (NC FET) 提供了潜在的好处,但修改后的协议,如修改后的NC FET和自然增殖期 (NPP) FET,可能会提高调度灵活性. 质阶段支持 (LPS) 在真NC FET中是有益的,但在修改NC FET中没有.

科学领域:

生殖内分泌学生殖内分泌学
辅助生殖技术辅助生殖技术
临床试验分析

背景情况:

为冷胚胎移植 (FET) 进行最佳子宫内膜制备正在调查中,自然循环 (NC) FET正引起人们对其潜在的孕产妇和产周益处的关注.
虽然观测数据支持NC FET,但后勤挑战限制了其广泛采用.
自然增殖期 (NPP) FET协议结合了生理优势和改进的调度灵活性.

研究的目的:

系统地审查和评估不同自然循环FET执行策略的生殖结果.
为了比较自然增殖期 (NPP) FET与其他FET协议.
在各种NC FET协议中评估黄质阶段支持 (LPS) 的影响.

主要方法:

在主要数据库 (MEDLINE,Embase,Global Health,Cochrane Library) 进行了全面的文献搜索,截至2024年11月.
包括的研究包括随机对照试验,非随机干预研究和观察性研究.
关键词包括"冷胚胎移植"",自然周期"",怀孕"",活产"和"分娩",没有语言或过器限制.

主要成果:

真NC FET的排卵周期与较高的活产率 (LBRs) 相比,与黄素化未破裂的卵泡周期 (非常低的确定性证据) 相比,与更高的活产率 (LBRs) 相关.
在真NC FET中,用阴道孕激素改善了LBR,但在修改NC FET中没有 (中度确定性证据).
与激素替代疗法 (HRT) FET (非常低确定性证据) 相比,自然增殖期 (NPP) FET显示较高的LBRs.

结论:

修改后的NC和NPP FET策略可能在生理益处和调度方便之间提供平衡,尽管高质量的证据有限.
对于真NC FET,建议使用常规LPS,但对于修改NC FET,不建议使用.
在不损害生殖结果的情况下,NPP FET显示出增强调度的前景,这证明了进一步高质量的研究是有希望的.

关键词:

毛囊阶段毛囊阶段在冷胚胎转移过程中,活生生的出生率是多少形阶段形期形阶段的支持.修改了自然循环的自然循环.自然增殖阶段的自然增殖阶段.这是真正的自然循环.

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