塑造Aspergillus niger成为L-酸的下一代细胞工厂
He Liu1, Mei-Yi Chang1, Chi Zhang1
1State Key Laboratory of Microbial Technology, Nanjing Normal University, Nanjing, Jiangsu 210000, China; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, Jiangsu 210000, China.
Current opinion in biotechnology
|February 14, 2026
概括
可持续的微生物发酵正在使用Aspergillus niger增强L-酸的生产. 本综述详细介绍了代谢工程和系统生物学方面的进展,以实现高效的L-酸合成和工业扩展.
科学领域:
- 生物技术是生物技术.
- 代谢工程是代谢工程.
- 工业微生物学 工业微生物学
背景情况:
- L-酸是一种关键的平台化学物质,需求日益增长.
- 微生物发酵提供了一个可持续的生产途径.
- 黑色阿斯伯吉洛斯是L-酸生物合成的高效宿主.
研究的目的:
- 审查最近在L-酸路径工程工程L-酸路径工程中取得的进展.
- 为了突出系统代谢工程策略增加L-酸产量.
- 讨论工业L-酸生产的挑战和未来前景.
主要方法:
- 关于A. niger.中的L-酸生物合成的文献综述.
- 系统代谢工程方法的分析.
- 讨论生物工艺强化和下游加工.
主要成果:
- 在理解和设计L-酸通路方面取得了重大进展.
- 成功地将碳流转向L-酸合成.
- 确定用于路径优化的关键工具和策略.
结论:
- 系统代谢工程和启用工具对于增强L-酸生产至关重要.
- 应对工艺强化等规模化挑战对于工业可行性至关重要.
- 将系统生物学与生物工艺创新的整合将推动经济生产.
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