美国瘤登记处的正常化乳腺癌生存结果
Tori C Nierenberg1, Kerri-Anne Crowell2, Samantha M Thomas3
1Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Cancer epidemiology
|February 14, 2026
概括
将国家癌症数据库 (NCDB) 和监测,流行病学和最终结果 (SEER) 种群与美国癌症统计局 (USCS) 种群的正常化显示,乳腺癌患者的整体存活率 (OS) 类似. 这些发现表明,使用NCDB和SEER数据的分析是可概括的.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 国家癌症数据库 (NCDB) 和监测,流行病学和最终结果 (SEER) 计划是癌症研究的重要资源.
- 然而,数据收集和患者人口统计学的差异可能会影响研究结果的概括性.
- 这项研究旨在通过将NCDB和SEER数据规范化为美国癌症统计 (USCS) 人口来解决这些潜在的局限性.
研究的目的:
- 为了使NCDB和SEER群体正常化,以反映USCS群体.
- 检查和比较乳腺癌患者在正常化前后的整体生存 (OS) 结果.
- 评估来自NCDB和SEER数据集的发现的概括性.
主要方法:
- 2010年至2018年间被诊断为I-IV期乳腺癌的患者从NCDB和SEER中进行了选择.
- 用患者加权的频率来使NCDB和SEER队列正常化,基于年龄,性别和种族/种族等变量,使用USCS的率.
- 总体存活率估计使用Kaplan-Meier方法在正常化前和后.
主要成果:
- 在USCS队列包括2,473,739名患者,NCDB 1,441,556,和SEER 504,938.
- 虽然年龄和性别分布相似,但在种族/种族组成和疾病程度方面观察到显著差异.
- 在按阶段,人力资源状况和种族/种族进行正常化后,在5年后的生存期中发现了轻微的变化,但整体存活率仍然相似,这表明数据集的稳定性.
结论:
- 像NCDB和SEER这样的美国瘤登记处为大量乳腺癌患者提供数据.
- 尽管存在人口和疾病范围的差异,但在正常化后,总体生存结果与USCS人口相似.
- 使用规范化NCDB和SEER数据的分析可能可以将其推广到更广泛的美国乳腺癌人口中.
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