乳腺保护疗法是40岁以下被诊断为乳腺癌的女性的安全选择
Arith Reyes1, Eunice Y Lee2, Courtney Connelly3
1Department of Surgery, Breast Surgery Division, Columbia University Medical Center, New York, NY.
The Journal of surgical research
|February 14, 2026
概括
乳腺保护疗法 (BCT) 是40岁以下被诊断患有乳腺癌的年轻女性的安全选择,其生存结果与乳腺切除术相似. 观察到的大多数复发都是远程转移,这表明局部治疗选择对整体结果的影响较小.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 乳腺癌发病率在年轻的绝经前妇女中正在上升.
- 乳房切除术和乳房保护疗法 (BCT) 对40岁以上的女性提供了类似的生存率,但对年轻女性的结果尚不清楚.
- 本研究涉及乳腺切除术与BCT在40岁或更年轻的女性中的比较有效性.
研究的目的:
- 评估接受乳腺切除术的年轻女性 (≤40岁) 的生存和复发风险与BCT.
- 为了比较两种治疗方式之间的总生存率和无复发生存率.
- 确定影响这一特定人口群体结果的因素.
主要方法:
- 对414名在40岁或更年轻时被诊断患有乳腺癌的女性 (1995-2020) 的回顾性审查.
- 乳房切除和BCT组之间的整体存活率和无复发存活率的比较.
- 多变量分析控制年龄,阶段,瘤亚型和BRCA状态.
主要成果:
- 在BCT和乳腺切除组之间,在5年总生存率或无复发生存率上没有统计学上显著的差异.
- 多变量分析证实BCT和乳房切除术之间死亡率或复发率没有显著差异.
- 远程转移是最常见的复发类型 (62%),这表明局部治疗选择对结果不那么重要.
结论:
- 乳腺保护疗法 (BCT) 是40岁及以下被诊断患有乳腺癌的女性的安全和可行的选择.
- 队列中的年轻女性比BCT更频繁地接受了乳房切除术,尽管存在类似的生存益处.
- 远程转移的高率表明,需要专注于全身疗法,以改善年轻乳腺癌患者的治疗结果.
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