AANG:一种天然化合物配方,用于针对非小细胞肺癌中的巨细胞-肌纤维细胞过渡
Max Kam-Kwan Chan1, Philip Chiu-Tsun Tang1, Zoey Zeyuan Ji1
1Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
概括
研究人员确定了巨细胞-肌纤维细胞过渡 (MMT) 作为非小细胞肺癌 (NSCLC) 癌症相关纤维细胞 (CAF) 的来源. 一种优化的传统中医药 (TCM) 配方,AANG,在临床前模型中有效地阻止了MMT和癌症进展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症相关纤维细胞 (CAF) 是瘤微环境 (TME) 的关键组成部分,表现出阻碍治疗发展的异质性.
- 巨细胞 - 肌纤维细胞过渡 (MMT) 已被确定为非小细胞肺癌 (NSCLC) 的前瘤CAF的重要来源.
研究的目的:
- 调查NSCLC内部Smad信号在MMT中的作用.
- 评估优化传统中医药 (TCM) 配方AANG在阻断MMT和随后的癌症进展方面的疗效.
主要方法:
- 临床NSCLC样本的空间单细胞生物信息学分析.
- 在体外研究中,使用骨髓衍生的巨细胞 (BMDM) 接受了优化AANG的治疗.
- 在NSCLC小鼠模型中AANG的体内评估 (LLC和A549异种移植).
主要成果:
- 空间单细胞生物信息学揭示了NSCLC中MMT巨细胞中的Smad3激活和Smad7减少.
- 优化了AANG调节的TGF-β1 / Smad3 / Smad7信号传输,在体外BMDM中有效地阻止MMT.
- 在体内,AANG在阻止MMT衍生的癌症进展方面表现出有效性,没有可观察到的副作用.
结论:
- 在NSCLC中,MMT是前瘤CAF生成的关键途径.
- 优化的AANG显示出作为一种新型治疗剂的潜力,用于向NSCLC中的MMT衍生的CAF.
- 在临床NSCLC中,AANG可能是第一个阻止MMT衍生的瘤前CAF形成的天然化合物配方.
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