确定与白质超强度相关的抑郁症中的关键枢纽和异常连接模式
Shuo Zhang1, Yikun Lu1, Zhongjian Tan2
1Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Asian journal of psychiatry
|February 14, 2026
概括
白质超强度 (WMH) 与抑郁症有关. 这项研究发现,在患有抑郁症的WMH患者中,三重网络 (DMN-SN-CEN) 功能连接模式和右上旋变化.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 白质超强度 (WMH) 与抑郁症的出现有显著的关联.
- 了解将WMH与抑郁症联系在一起的病理机制对于开发有针对性的干预措施至关重要.
研究的目的:
- 调查WMH相关抑郁症的潜在病理机制.
- 用多式神经成像分析大脑结构和功能网络的变化.
主要方法:
- 招募了48名患有抑郁症的WMH患者 (WMH-D),47名没有抑郁症的WMH患者 (WMH-ND) 和50名健康的对照人 (HC).
- 低频波动的利用幅度 (ALFF) 用于功能连接 (FC) 分析和基于voxel的形态学 (VBM) 用于结构分析.
- 进行神经成像发现与临床特征之间的相关性分析.
主要成果:
- 在WMH-D患者中,中央执行网络 (CEN) 和默认模式网络 (DMN) 之间的FC降低,CEN- Salience网络 (SN) 连接性增加,表明三重网络失调.
- 在右上旋 (STG) 的同时发生的结构和功能变化与抑郁症的严重程度和疾病持续时间有积极的相关性.
结论:
- 确定了一个三重网络 (DMN-SN-CEN) 功能连接签名作为WMH相关抑郁症的潜在神经成像生物标志物.
- 右侧的STG异常可能代表神经基质,将大脑血管病理与抑郁症状联系起来.
- 在STG中重叠的结构和功能缺陷为早期干预提供了一个有希望的治疗目标.
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