成年人接触个人护理产品和甲状腺功能:揭示关联和潜在机制
Hui Zou1, Jinyan Zhong1, Xing Wei1
1Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong 511436, China; Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511416, China.
接触个人护理产品 (PCP) 与甲状腺功能降低有关,特别是总甲状腺素 (TT4). 通过中性粒细胞与血小板的比率 (NPR) 表示的全身炎症,部分调解了这些影响.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 个人护理产品 (PCP) 是内分泌干扰化学品 (EDC) 的常见来源.
- 来自PCP的EDC对甲状腺功能的综合影响尚不清楚.
- 目前正在研究EDC对甲状腺影响的机制.
研究的目的:
- 为了研究PCP的尿路代谢物与甲状腺功能之间的关联.
- 评估PCP混合物对甲状腺激素的综合作用.
- 探索系统性炎症在这些关联中的调解作用.
主要方法:
- 从2007-2012年NHANES中对2714名成年人的分析.
- 个人化学协会的调查加权线性回归.
- 量子g计算 (QGC) 和贝叶斯内核机器回归 (BKMR) 用于混合效应.
- 因果调解分析,以评估系统性炎症的作用 (中性粒细胞与血小板细胞的比例).
主要成果:
- 大多数尿PCP代谢物与剂量依赖的甲状腺功能减弱 (TT4,FT4) 相相关.
- 特定的化学物质如双甲,基-3,和パラベン显示出与降低TT4.4的显著关联.
- PCP混合物始终与较低的FT4和TT4有关,其中双A,三三和某些类甲是主要贡献者.
- 通过中性粒细胞与血小板比率 (NPR) 测量系统性炎症,部分介导了PCP代谢物与甲状腺功能之间的关联.
结论:
- 对PCP的单个和联合暴露都与甲状腺功能受损有关.
- 系统性炎症在PCP和甲状腺功能之间的关系中发挥着部分调解作用.
- 调查结果强调需要对PCP中的EDC进行监管,并评估联合暴露风险.
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