儿童睡眠呼吸障碍的血液学指数:一个回顾性病例对照研究
Rita Teixeira Carvalho1, Francisco Alves de Sousa2, João Carvalho Almeida3
1Otorhinolaryngology and Head & Neck Surgery, Unidade Local de Saúde de Santo António, Largo do Prof. Abel Salazar, 4099-001, Porto, Portugal.
International journal of pediatric otorhinolaryngology
|February 14, 2026
概括
儿科阻塞性睡眠呼吸障碍 (OSDB) 与较高的中性粒细胞与淋巴细胞比率和血小板数量有关. 这些发现表明OSDB儿童的潜在炎症反应,需要进一步调查.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 血液学 血液学 血液学
- 睡眠医学 睡眠医学
背景情况:
- 儿科阻塞性睡眠呼吸障碍 (OSDB),通常是由于腺突增大, presents一个诊断挑战.
- OSDB可能导致全身炎症,氧化应激,以及潜在的代谢,心血管和神经认知并发症.
- 血液学生物标志物正在被探索作为潜在的诊断工具,由于多睡眠学的资源需求.
研究的目的:
- 为了比较被诊断患有OSDB的儿童与没有这种疾病的儿童的血液学参数.
- 在儿科OSDB中调查潜在的炎症标志物.
主要方法:
- 对接受耳鼻喉科手术的儿童手术前血液学数据的回顾性分析.
- 与OSDB (病例) 的队列和没有OSDB的对照组之间的血液学参数的比较.
- 在2024年1月至5月期间,包括166名患者 (85名OSDB).
主要成果:
- 与对照组相比,患有OSDB的儿童的中性粒细胞与淋巴细胞 (N/L) 比率 (p=0.026) 和血小板计数 (p=0.025) 显著提高.
- 两组之间没有观察到年龄,性别或体重的显著差异.
- 中性粒细胞数,白细胞总数和血小板与淋巴细胞的比率没有显示出统计学上显著的差异 (p > 0.05).
结论:
- 儿科OSDB与高N/L比率和血小板数量有关,表明可能存在系统性炎症过程.
- 这些血液学变化可能成为儿童OSDB的潜在生物标志物.
- 需要进行进一步的研究,以阐明这些血液学发现在儿科OSDB中的临床影响.
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