长期使用二和Z型药物:台湾的一项基于登记的队列研究
Meng-Chiao Chou1, Yueh-Pin Lin1, Chun-Hung Pan2
1Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
Drug and alcohol dependence
|February 14, 2026
概括
长期使用二 (BZD) 和Z药在台湾并不常见,影响3.8%至14.7%的患者. 预测因素包括老年,男性性别和某些并发症,需要有针对性的监测.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 类药物 (BZDs) 和Z药物广泛用于治疗焦虑和失眠.
- 长期使用这些药物对公众健康构成重大关注.
- 关于亚洲人群中长期BZD和Z药物使用模式的证据有限.
研究的目的:
- 调查长期使用二和Z药物的轨迹和预测因素在台湾.
- 用基于人口的队列分析使用模式.
- 为了确定与持续使用药物相关的因素.
主要方法:
- 一项基于登记的队列研究,利用台湾国家健康保险研究数据库 (NHIRD).
- 在20年 (2000-2019) 期间对事件用户进行分析,其中1年的时间被淘汰.
- 考克斯回归模型用于根据人口,身体和精神因素确定长期使用的调整危险比率 (aHR),使用90天和365天的停药值.
主要成果:
- 在896163名偶尔使用者中,3.8% (90天定义) 和14.7% (365天定义) 逐步进入长期使用.
- 根据90天的定义,克罗纳泽帕姆和催眠性BZD表现出最高的持久率 (分别为10.3%和8.4%).
- 超过70%的启动发生在非精神病学环境中. 长期使用与男性性别,年龄较大和更高的并发症得分 (查尔森并发症指数) 有关,癌症,肺炎,脏病和某些精神障碍是强烈的预测因素.
结论:
- 在台湾,大多数的二胺 (BZD) 和Z药物处方是短期的.
- 临床和系统层面的因素都会影响药物使用模式.
- 调查结果强调需要基于风险的监测,监督跨专业的处方,以及对替代治疗的研究.
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