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评估晚成熟的冷保存卵细胞的生殖潜力
Keri Bergin1, Ashna Mehra2, Rick Slifkin2
1Reproductive Medicine Associates of NY, New York, NY, USA; Icahn School of Medicine Mount Sinai, New York, NY, USA.
Reproductive biomedicine online
|February 14, 2026
概括
与立即成熟的卵子相比,晚成熟的冷保存卵子具有较低的受精和胚胎发育潜力. 然而,这些晚期成熟的卵细胞仍然可以产生高质量的芽细胞,提供进一步的家庭建设选择.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 低温生物学 低温生物学
背景情况:
- 卵细胞冷保存是辅助生殖的一个关键技术.
- 卵细胞在冷保存时的成熟状态可以影响结果.
- 晚期成熟的卵细胞,需要在体外成熟的救援,呈现出一个独特的子组.
研究的目的:
- 为了比较晚成熟的冷保存卵子与立即成熟的冷保存卵子的变暖,受精和胚胎发育结果.
- 根据其在冷保存时的成熟状态来评估卵细胞的生殖潜力.
主要方法:
- 自体卵细胞冷保存周期的回顾性队列研究 (2016年1月 - 2024年9月).
- 第1组:卵子在获取时成熟 (转化阶段II).
- 第二组:晚期成熟的卵子细胞 (在救援后在体外成熟后达到基因相II).
- 统计分析包括威尔科克森等级总和测试,奇平方测试和后勤回归.
主要成果:
- 变暖生存率在各组之间是相似的 (79.4%对78.0%).
- 与晚期成熟卵细胞 (59.8%) 相比,立即成熟卵细胞 (75.3%) 的受精率显著更高.
- 立即成熟的卵细胞显示出明显更高的爆发率 (37.7%与26.1%) 和euploidy率 (54.5%与39.3%).
结论:
- 晚期成熟的冷保存卵子表现出与在取回时成熟的卵子相比,其生殖潜力下降,这可能是由于异步成熟.
- 尽管发育率较低,但迟成熟的卵细胞仍然可以发展成为高质量的胚芽细胞.
- 这些发现为生育保护策略和患者咨询提供了宝贵的见解.
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