绝对定量蛋白质组学识别了与结直肠癌患者静脉血栓栓塞相关的血蛋白的模式
J T Buijs1, N van Es2, C Englisch3
1Einthoven Laboratory for Vascular and Regenerative Medicine, Division of Thrombosis and Hemostasis, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
Thrombosis research
|February 14, 2026
概括
结肠直肠癌患者有高风险的静脉血栓栓塞 (VTE). 这项研究确定了六种血蛋白,可以帮助预测这些患者的静脉瘤风险,优于现有的模型.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 癌症患者面临着静脉血栓塞栓症 (VTE) 的显著增加风险,大约是普通人群的11倍.
- 结肠直肠癌,特别是晚期 (III/IV) 结肠直肠癌与风险增加有关.
- 现有的VTE风险预测模型可能无法完全捕捉癌症患者VTE的复杂性.
研究的目的:
- 为了研究结直肠癌患者的血蛋白水平,有或没有血栓形成.
- 为了确定用于预测结直肠癌中VTE的新型蛋白质生物标志物.
- 将已识别的蛋白质的预测性能与已建立的VTE风险模型进行比较.
主要方法:
- 对269个血蛋白进行了有针对性的绝对量化.
- 分析了两个前性队列研究 (MICA和CATS),包括III/IV期结直肠癌患者.
- 在6个月和2年的随访期间,对静脉瘤事件 (深静脉血栓或肺栓塞) 进行了监测.
主要成果:
- 在MICA队列中发现了六种差异丰富的蛋白质 (DAP):APOB100,CD5L,IGHG1,IGHM,PRG4和TF.
- 使用这六个DAP的预测模型在内部交叉验证中实现了0.675的c统计 (乐观度纠正).
- DAP模型在CATS队列中显示出预测价值 (6个月的c-统计值为0.70,2年的随访值为0.73),表现优于既有模型.
- 两种蛋白质显示出队列之间的反转模式,可能是由于化疗效应.
结论:
- 已识别的六种血蛋白显示出作为新型生物标志物在结直肠癌患者中预测VTE风险的前景.
- 与现有的临床风险评分相比,开发的基于蛋白质的模型提供了优越的预测性能.
- 需要在更大的标准化研究中进行进一步验证,以确认这些发现及其临床实用性.
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