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唐氏综合征成年人的阻塞性睡眠呼吸暂停:身体组成,代谢概况和认知状态

Lígia Fidelis Ivanovic¹, Cristiana Castanho de Almeida Rocca², Rosa Hasan²

¹Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Clinics (Sao Paulo, Brazil)

|February 14, 2026

概括

阻塞性睡眠呼吸暂停 (OSA) 影响63%的唐氏综合征 (DS) 的成年人,与代谢问题和记忆力低下相关. 这凸显了在这个人群中需要进行OSA查的必要性.

科学领域:

医学研究医学研究
遗传学是一个遗传学.
睡眠医学睡眠医学

背景情况:

唐氏综合症 (DS) 是智力障碍的主要原因,通常伴有医疗条件.
阻塞性睡眠呼吸暂停 (OSA) 在DS患者中非常普遍,超过一般人群的比率.
在DS成年人中,OSA的临床影响,特别是心血管,代谢和神经认知风险,研究不足.

研究的目的:

确定患有DS的成年人中OSA的患病率和特征.
调查OSA与身体组成,代谢状态,功能能力和认知表现之间的关联.

主要方法:

一项涉及34名患有DS的成年人 (≥18岁) 的横截面研究.
评估包括人体测量,多睡眠学 (PSG),神经心理测试,生化标志物和功能尺度.
在临床,人体,功能和认知变量方面,在有和没有OSA的受试者之间进行了比较.

主要成果:

63%的DS参与者被诊断出OSA (呼吸暂停-呼吸暂停指数≥5次/小时).
OSA与男性性别,增加子周长,腹部脂肪,较高的缩血压,改变的葡萄糖代谢和较低的HDL胆固醇有关.
患有OSA的人在口头记忆任务中表现较差.

结论:

患有唐氏综合征的成年人表现出阻塞性睡眠呼吸暂停的高发病率.
在这一群体中,OSA与不良的代谢概况和记忆功能下降有关.
研究结果表明,日常OSA查和管理对于患有DS的成年人来说至关重要.

关键词:

身体组成身体组成认知认知是一种认知.唐氏综合征是什么意思唐氏综合征记忆记忆记忆记忆记忆睡眠呼吸暂停,阻塞性呼吸暂停.

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