在爱尔兰保护婴儿免受呼吸道同胞病毒 (RSV):国家尼尔塞维马布免疫计划的影响,2024/2025年
Laura Paris1, Lisa Domegan2, Maureen O'Leary2
1European Centre for Disease Prevention and Control (ECDC) Fellowship Programme, Field Epidemiology path (EPIET), ECDC, Stockholm, Sweden; Health Service Executive- Health Protection Surveillance Centre, Ireland.
Vaccine
|February 14, 2026
概括
爱尔兰 爱尔兰 爱尔兰 爱尔兰 爱尔兰 爱尔兰
科学领域:
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 爱尔兰在2024/2025赛季推出了一项针对呼吸道同胞病毒 (RSV) 的全国免疫计划.
- 在2024年9月至2025年2月之间出生的婴儿有资格接受长期起作用的单克隆抗体,用于RSV预防的nirsevimab.
研究的目的:
- 评估nirsevimab免疫计划在减少爱尔兰符合条件的婴儿中RSV相关疾病的有效性.
主要方法:
- 一项以人口为基础的回顾性生态研究分析了2024/2025赛季RSV病例和临床结果.
- 将2024/2025年数据与历史RSV季节 (2023/2024年和2022/2023年) 的数据进行比较.
- 使用适应的公式计算了避免的病例,疾病预防的分数和免疫所需的数量 (NNI).
主要成果:
- 83%的符合条件的婴儿在2024/2025赛季接受了nirsevimab.
- 与2023/2024赛季相比,RSV病例减少了68%,与2022/2023赛季相比减少了64%.
- 该计划避免了1055例RSV病例,459次急诊,437次住院和76次重症监护室入院,疾病预防率为74.5%.
结论:
- 在2024/2025赛季期间,尼尔塞维马布免疫剂显著降低了爱尔兰婴儿的RSV相关发病率.
- 这些发现支持尼尔塞维马布的持续使用,并表明可能扩展到老年婴儿群体.
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