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氨酸电纳米纤维贴片用于加速慢性复发性口腔口腔的

Mohamed Sharaf¹, Shufang Xu², Hu Tiantian²

¹Department of Biochemistry and Molecular Biology, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, PR China; Department of Biochemistry, Faculty of Agriculture, AL-Azhar University, Nasr City, Cairo, 11751, Egypt.

International journal of biological macromolecules

|February 14, 2026

概括

由多巴胺交叉链接的氨酸 (HA) 制成的新型生物可吸收纳米纤维贴片有效治疗复发性口腔. 这种粘膜粘合剂,抗菌和治疗补丁促进了粘膜的快速再生,并安全地被吸收.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
纳米技术纳米技术

背景情况:

复发性口腔 (RAU) 是一个临床挑战,需要先进的治疗策略.
目前的治疗方法往往缺乏有效性,导致长时间的愈合和不适.
开发多功能生物材料对于有效的RAU管理至关重要.

研究的目的:

开发和描述一种新的生物可吸收纳米纤维贴片,用于治疗复发性口腔.
将粘膜粘合,抗菌性质和促愈能力结合到一个单一的伤口包裹中.
为了评估开发的纳米纤维贴片的*in vitro*和*in vivo*疗效和安全性.

主要方法:

多巴胺交叉连接的氨酸 (HA) 纳米纤维的电,然后用e-poly-l-lysine (EPL) 进行后交叉连接.
纳米纤维形态的表征,化学成分 (UV-vis,FT-IR,SEM) 和物理特性.
评估体外生物相容性 (血液溶解,细胞毒性) 和伤口愈合潜力 (划伤试验).
在老鼠RAU模型中*in vivo*疗效的评估,评估粘附性,细菌负载,炎症,愈合和再吸收.

主要成果:

统一的多巴胺交联HA/EPL纳米纤维 (DHA-EPLNFs) 已成功制造,证实了catechol和EPL的结合.
DHA-EPLNFs补丁表现出极好的生物相容性,血液溶解最小,对口腔角质细胞没有细胞毒性.
实验室研究显示,加快了痕的关闭,这表明它具有治疗性质.
在老鼠RAU模型中,该贴片表现出强大的粘粘度,显著的细菌减少 (2-log),减少炎症,并在6天内实现95%的粘膜再生.
补丁的完全再吸收发生在8天内,没有任何不良影响,性能优于商用 прополис口服膜.

结论:

开发的多功能DHA-EPLNFs贴片是治疗复发性口腔的有希望,安全和有效的替代疗法.
在可生物吸收的格式中,粘膜粘合,抗菌活性和治疗性质的结合提供了显著的优势.
这种纳米纤维技术为加速粘膜再生和改善临床结果提供了一种患者友好的方法.

关键词:

抗菌的抗菌的抗菌的细胞的增殖和迁移.细胞毒性细胞毒性氨酸是什么? 氨酸是什么?纳米纤维是一种纳米纤维.复发的腹痛性的.

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