凝增强的PCL纳米纤维注入香精油,具有多功能性能,用于伤口包裹应用
Priya Verma1, Raj Kumar Sen2, Pallavi Shukla1
1Microbial Technology Division, CSIR-National Botanical Research Institute (CSIR-NBRI), Rana Pratap Marg, Lucknow, 226001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
International journal of biological macromolecules
|February 14, 2026
概括
这项研究开发了先进的抗微生物伤口包裹,使用聚烯酸 (PCL) 和质 (GEL) 纳米纤维与提精油 (TEO). 混合PCL:GEL_T15纳米纤维显示出出色的结构,抗氧化和抗微生物特性,可有效地治愈伤口.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口愈合 治愈 伤口愈合
背景情况:
- 伤口愈合涉及复杂的生物相互作用,需要有效的管理策略.
- 电纳米纤维为伤口带提供有前途的仿生特性,包括可控药物输送.
- 聚卡普罗拉克 (PCL) 和西瓜精油 (TEO) 正在探索它们在伤口护理应用中的潜力.
研究的目的:
- 为了制造和表征与提精油 (TEO) 结合的聚烯酸 (PCL) 纳米纤维.
- 开发一种混合纳米纤维系统 (PCL:GEL_T15) 通过结合凝 (GEL) 来增强伤口包特性.
- 评估开发的混合纳米纤维的物理化学,抗氧化和抗菌疗效.
主要方法:
- 通过电制造具有不同TEO度 (5-20%) 的PCL纳米纤维.
- 开发一种混合PCL:GEL_T15纳米纤维系统.
- 纤维形态的表征,水友性 (水接触角度) 和TEO释放动力学.
- 对黄金葡萄球菌 (MRSA) 和大肠杆菌 (E. coli) 的抗菌活性的评估.
- 对生物膜抑制,抗氧化能力 (自由基清除) 和细菌膜完整性的评估.
主要成果:
- PCL_T15纳米纤维显示出最佳的统一性和电可性.
- 混合PCL:GEL_T15系统证明了纤维形态的改善,增强了水友性 (水接触角度减少到38.67°),并控制了TEO释放.
- PCL:GEL_T15纳米纤维表现出强大的抗菌功效,在12-24小时内根除MRSA和大肠杆菌,具有>95%的生物膜抑制.
- 抗氧化剂测定显示>90%的自由基清除能力.
- 细菌活力测定证实了膜损伤和细胞死亡.
结论:
- PCL:GEL_T15混合纳米纤维具有卓越的结构,抗氧化和抗菌功能.
- 这些混合纳米纤维代表了有效的抗微生物伤口包裹的先进材料.
- PCL,GEL和TEO的协同组合可以提高伤口愈合潜力.
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