在四种精神疾病中,情绪处理恢复的共同网络
Yueling Liu1, Wenqiang Xu2, Xiya Zhao2
1School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.
研究人员确定了一种共同的大脑网络,用于跨精神疾病的情绪处理恢复 (EPR). 这种在岛膜和膜中固定的网络显示出针对情绪缺陷的跨诊断治疗的前景.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 异常的情绪处理是精神疾病的核心缺陷,是药物治疗的目标.
- 对于情绪处理恢复 (EPR) 的神经成像发现目前是异质的,阻碍了治疗的发展.
研究的目的:
- 为了使药物治疗诱导的EPR异质神经成像发现与一个共同的大脑网络相协调.
- 通过纵向患者数据验证这个网络,并评估它在治疗模式上的通用性.
主要方法:
- 在四种精神疾病中对药物治疗诱导的EPR进行了23项神经成像研究 (n=652) 的元分析.
- 治疗网络映射方法应用于功能连接组数据.
- 从213名患者收集了纵向fMRI和情绪数据,用于临床验证.
主要成果:
- 确定了EPR的208个大脑激活坐标,将其协调成一个共同的网络,该网络定在双边的insula和putamen中.
- 这种EPR网络与精神病学遗传和神经递质特征保持一致,一般化为电治疗,但不是心理治疗.
- 有效的情绪治疗目标与这个网络共同定位;增强的功能连接预测了情绪改善.
结论:
- 跨精神疾病的异质EPR发现可以在一个共同的大脑网络中统一.
- 这种跨诊断EPR网络为开发新的以情绪为中心的治疗提供了潜在的基础.
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