心房隔膜缺陷的关闭使儿童和青少年的左室和右室血动力学力量正常化
Per M Arvidsson1, Henning Clausen2, Pia Sjöberg1
1Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Clinical Physiology, Skåne University Hospital, Lund, Sweden.
概括
前庭隔膜缺陷 (ASD) 关闭改善了心室中的血动力学力 (HDF). 虽然RV HDF在术后恢复正常,但LV HDF的变化表明先天性心脏病患者正在进行重塑.
科学领域:
- 心血管成像和血液动力学
- 遗传性心脏病研究 遗传性心脏病研究
- 生物医学工程 生物医学工程
背景情况:
- 前庭隔膜缺陷 (ASD) 导致慢性右心室 (RV) 体积过载,可能导致心力衰竭.
- 目前的治疗方法 (手术/透导管关闭) 改善了血液动力学,但对心室内血液动力学力 (HDF) 的影响尚不清楚.
研究的目的:
- 评估ASD关闭对双心室硬膜纤维的影响.
- 了解先天性心脏病中的心室重塑.
主要方法:
- 心脏磁共振成像 (1.5T) 使用4D流和电影序列.
- 定制软件用于从成像数据计算HDF.
- 配对分析比较HDF在ASD关闭之前和之后.
主要成果:
- 在ASD患者的基线RV HDF异常,与体积负载相关.
- 关闭后8个月,RV HDF正常化,而LV HDF显示方向变化.
- HDF变化与心室体积重塑和分流减小有关.
结论:
- 由于负载条件,ASD患者表现出改变的室腔HDF.
- 在许多情况下,ASD关闭会使HDF正常化,但并非所有情况下.
- HDF分析提供了对先天性心脏病中心室重塑的见解.
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