在阻塞性睡眠呼吸暂停症中,近距离低神经刺激的三年结果
Alan R Schwartz1, Ofer Jacobowitz2, Samuel A Mickelson3
1Department of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Otolaryngology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Chest
|February 14, 2026
概括
有针对性的近端下神经刺激 (THN) 可以安全有效地治疗睡眠呼吸障碍,长达三年. 这项长期研究表明,与其他方法相比,呼吸和生活质量持续改善.
科学领域:
- 医疗器械 医疗器械
- 睡眠医学 睡眠医学
- 神经调节是一种神经调节.
背景情况:
- 有针对性的近端下神经刺激 (THN,pHGNS) 已证明在一年内改善睡眠呼吸障碍,睡眠结构和生活质量 (QOL) 的有效性.
- 在THN3试验中,为pHGNS.pHGNS建立了有利的安全概况.
研究的目的:
- 评估pHGNS的长期 (3年) 安全性和有效性.
- 为了比较pHGNS的长期结果与STAR试验的远部下神经刺激 (dHGNS).
主要方法:
- 该THN3试验招募了中度至重度阻塞性睡眠呼吸暂停 (AHI 20-65 / hr) 和BMI ≤35 kg/m2的参与者.
- 安全性和有效性通过不良事件,呼吸暂停-呼吸暂停指数 (AHI),氧气不和指数 (ODI),睡眠时间百分比与氧气和率<90% (T90) 以及24个月和36个月的QOL进行评估.
- pHGNS结果与基线和11个月数据以及dHGNS结果进行了比较.
主要成果:
- 75%的THN3参与者完成了为期3年的随访.
- 与基线相比,pHGNS在24个月和36个月的睡眠呼吸障碍,氧化和QOL持续改善.
- 长期结果与11个月的结果相比,有显著的AHI减少和大效果大小. 3年后,效益似乎与dHGNS相比.
结论:
- 在一年内观察到的pHGNS的治疗效果在三年内保持下来.
- 在pHGNS中,不良事件的发生率很低,这表明长期安全性是有利的.
- 这些发现表明pHGNS是阻塞性睡眠呼吸暂停 (OSA) 的安全有效的长期治疗选择,其结果与dHGNS相似.
相关概念视频
Sleep Apnea
599
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
599
Insufficient Sleep and Sleep Deprivation
963
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
963
Predicting Reaction Outcomes
11.0K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Stages of Sleep
1.5K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.5K
Outcomes of Glycolysis
107.8K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.8K
Understanding Sleep
1.6K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.6K


