一种新型的GIPR/GLP-1R双重激动剂通过差异调节肥胖症炎症和脂质代谢来改善系统代谢

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Updated: Feb 16, 2026

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Feng Zhang¹, Wei Chen², Huiying Wang²

¹National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Neurodegenerative Diseases, Changsha Medical University, Changsha, China.

Journal of advanced research

|February 14, 2026

概括

像THDBH120这样的双GIP/GLP-1受体激动剂在治疗肥胖和2型糖尿病方面表现有前途. THDBH120通过GLP-1R改善脂质代谢,并通过GIPR减少炎症,突显了这两种受体对代谢健康的重要性.

科学领域:

代谢研究研究代谢研究
药理学药理学是指药理学的学科.
内分泌学在内分泌学.

背景情况:

双GIP/GLP-1受体激素因其在治疗肥胖和2型糖尿病方面的有效性而得到认可.
它们的全身代谢作用背后的精确机制需要进一步阐明.

研究的目的:

为了研究新型双重激素THDBH120的代谢作用.
确定GIPR和GLP-1R在脂肪组织和系统中介这些效应中的特定作用.

主要方法:

在体外实验中使用表达GIPR或GLP-1R的HEK293细胞进行功效测试.
在肥胖动物和非人类灵长类动物的体内疗效研究.
对用THDBH120,半氨酸或LAGIPRA治疗的GLP-1R和GIPR淘汰赛小鼠的分析,包括脂肪组织的转录组分析.

主要成果:

在临床前模型中,THDBH120表现出优异的体重减轻和代谢改善.
通过THDBH120或semaglutide激活GLP-1R可以增强脂质代谢.
通过THDBH120或LAGIPRA激活GIPR可缓解炎症,THDBH120通过脂肪组织中的两个受体特定通路起作用.

结论:

GLP-1R和GIPR都对双重激动剂的系统代谢益处至关重要.
THDBH120是一种强效,长效的双GIPR/GLP-1R激动剂,在代谢障碍中具有显著的临床应用潜力.

关键词:

脂肪组织的脂肪组织.它是GIPR/GLP-1R双重激素的双重激素.炎症炎症是一种炎症.脂质代谢脂质代谢是什么肥胖问题肥胖问题

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