在接受手术或放射治疗的前列腺癌患者中,膀和直肠癌的发展:基于人口的研究
P Martínez Rodríguez1, A Poza Fernandez1, G García Fadrique1
1Hospital de Manises, Manises, Valencia, Spain.
Actas urologicas espanolas
|February 14, 2026
概括
与激进性前列腺切除术 (RP) 相比,前列腺癌的放射治疗 (RT) 会增加盆腔瘤和直肠/尿路毒性的风险. 这项研究强调了RT在前列腺癌治疗中的潜在副作用.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 激进前列腺切除术 (RP) 和放射治疗 (RT) 是局部和局部晚期前列腺癌 (PCa) 的主要治疗方法.
- 关于盆腔恶性瘤和辐射诱导的直肠或尿道毒性,数据有限.
- 勃起功能障碍和尿失禁是经过充分记录的副作用.
研究的目的:
- 为了比较前列腺癌的RP和RT之间的盆腔瘤发生率和与治疗相关的毒性.
- 评估在接受RT与RP治疗的患者中发生二次恶性瘤和毒性的风险.
主要方法:
- 在2010-2019年间,对356名局部/局部晚期PCa患者进行了回顾性分析,这些患者接受了RP (138) 或RT (218) 治疗.
- 结直肠/膀瘤和尿路/胃肠道毒性的比较,使用奇平方和逻辑回归.
- 对临床变量进行调整的多变量分析.
主要成果:
- 两组之间瘤阶段或吸烟状况没有显著差异.
- 在RT组中,盆腔瘤 (p=0.032) 和膀瘤 (p=0.033) 的发病率较高.
- RT显著增加了尿路和胃肠道毒性 (p<0.001),膀瘤的风险增加了11倍.
结论:
- 与RP相比,前列腺癌的RT与盆腔瘤和尿道/直肠毒性更高的发病率有关.
- 这些发现强调了对RT治疗患者的二次恶性瘤和毒性监测的重要性.
- 需要进一步的研究来优化RT技术并减轻这些风险.
相关概念视频
Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Cancer
54.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.6K
What is Cancer?
14.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K
Imaging Studies I: Kidney, Ureter, and Bladder Studies
394
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
394
Cancer Vaccines
1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Skin Cancer
6.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.1K


