在小鼠中,压力敏感的中岛活动与饮酒和禁酒期间的负面影响类行为有关
Benjamin M Williams1, Jincy R Little1, Samuel W Centanni1
1Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Neuropharmacology
|February 14, 2026
概括
压力显著影响酒精使用障碍 (AUD) 通过增加戒断期间的负面情绪. 针对insula-BNST大脑电路可能为AUD和与压力相关的疾病提供新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 成研究 研究成研究
背景情况:
- 压力是导致酒精使用障碍 (AUD) 发展和复发的主要因素.
- 了解AUD中压力反应的神经生物学基础对于开发有效治疗方法至关重要.
- 禁欲期间长期存在的负面情绪状态 (hyperkatifeia) 是AUD的一个关键特征.
研究的目的:
- 调查成年人应激反应与酒精使用障碍中的高卡提菲亚之间的关系.
- 探索中岛和岛岛BNST电路在调解压力对饮酒和戒酒行为的作用.
- 确定治疗AUD相关情感脆弱性的潜在神经点.
主要方法:
- 使用的C57BL/6J小鼠经历了反复的束压力.
- 测量了饮酒期间的乙醇消耗和厌恶行为.
- 使用GCaMP成像记录了中岛神经活动.
- 在压力期间使用化学遗传学来抑制insula-BNST电路.
- 进行集群分析以识别不同的行为表型.
主要成果:
- 重复的压力增加了戒断期间的厌恶行为,但没有改变乙醇消费.
- 中岛神经活动与乙醇消费负相关,与戒断行为正相关.
- 在压力期间,insula-BNST电路的化学遗传抑制显示了对乙醇消费和厌恶行为的性别特异性影响.
- 压力诱导的insula-BNST抑制使雌性小鼠转向低乙醇消耗和避免的表型,但不是雄性.
结论:
- 在AUD戒断期间,insula-BNST电路参与调解压力反应,压力诱导的饮酒和情感脆弱性.
- 这一电路代表了AUD中超高卡提菲亚的潜在生物标志物和治疗点.
- 这些发现突出了insula-BNST电路在压力和酒精相互作用中的性别特异性作用.
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