抗生素耐受性和感染性内心炎的安全性:专注于老年患者
Capucine Richard1, Sylvain Gautier2, Pierre Boisson DE Chazournes3
1Geriatrics department, University Hospital A. Paré, Versailles St Quentin University, APHP, Boulogne-Billancourt, France.
Infectious diseases now
|February 14, 2026
概括
患有传染性内心炎 (IE) 的老年人能很好地耐受抗生素,但认知障碍会增加不良事件的风险. 年龄本身并不是IE患者抗生素耐受性的重要因素.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 老年病的医生 老年病的医生
背景情况:
- 传染性内心炎 (IE) 是一种严重的疾病,死亡率高,不成比例地影响老年人.
- 关于老年IE患者抗生素耐受性的数据有限.
研究的目的:
- 为了评估65岁以上被诊断为IE的患者的抗生素耐受性.
- 在这个人群中确定与抗生素相关不良事件 (AE) 相关的因素.
主要方法:
- 巴黎地区65岁以上IE患者的医院网络队列研究 (2016年5月 - 2024年8月).
- 在随访后的六个月内,系统地收集与抗生素相关的副作用.
主要成果:
- 83名患者中有25.3%经历了AE;认知障碍与更高的AE风险有关,特别是在≥75.5的患者中.
- 副作用与更长的住院时间有关,但与年龄,自主性或住院结果的差异无关.
- 阿莫西西林和塞法索林经常与AE有关,而链球菌IE则较少出现AE.
结论:
- 在老年IE患者中,抗生素耐受性通常很好.
- 认知状态,而不仅仅是年龄,是老年IE患者抗生素相关不良事件的关键预测因素.
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