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针对 lncRNA 中介网络,以克服癌症中多克索鲁比抗性

Mengru Qiu¹, Zhaoting Wang², Yuanyin Teng³

¹Department of Occupational Pulmonary Disease, Shandong Academy of Occupational Health and Occupational Medicine, Occupational Disease Hospital of Shandong First Medical University (Shandong Province Hospital Occupational Disease Hospital), Jinan, Shandong, China.

Critical reviews in oncology/hematology

|February 14, 2026

概括

长非编码RNAs (lncRNAs) 通过调节关键癌症途径来驱动对多克索鲁比 (DOX) 化疗的耐药性. 针对这些lncRNAs提供了一种有前途的策略,以克服耐药性并改善癌症治疗.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

多克索鲁比 (DOX) 是化学疗法的基石,但其有效性因获得的耐药性而受到影响.
长非编码RNAs (lncRNAs) 越来越多地被认为是癌症药物耐药性的关键调节者.
lncRNAs影响多个涉及DOX耐药性的细胞过程,包括生存,亡和新陈代谢.

研究的目的:

审查 lncRNAs 在各种癌症类型中调解多克索鲁比辛耐药性的机制性作用.
探索针对lncRNA及其下游途径的治疗策略,以克服DOX耐药性.
为开发基于 lncRNA 的癌症疗法提出一个翻译框架.

主要方法:

综合跨癌症证据的IncRNAs和DOX耐药性的综合文献综述.
分析 lncRNA 调节机制,包括 ceRNA 网络和信号枢纽.
评估治疗机会,包括直接的 lncRNA 向和新型药物输送系统.

主要成果:

lncRNAs通过PI3K/AKT/mTOR,亡调节 (BCL-2,MCL1) 和自等保护途径协调DOX耐药性.
lncRNA介导的耐药性涉及复杂的相互作用,包括竞争的内源RNA (ceRNA) 网络.
针对lncRNAs,下游途径或利用先进的交付平台的治疗干预显示出潜力.

结论:

lncRNAs是DOX抗性的关键调节者,为癌症治疗提供可用药物的标.
整合机理性见解和临床策略的翻译框架对于开发基于 lncRNA 的干预措施至关重要.
准 lncRNA 具有克服化疗抵抗和推进精确瘤学的前景.

关键词:

收信号通道的信号通道.对多克索鲁比的耐药性长非编码RNA是什么意思精确瘤学是一门精确的专业.ceRNA 网络的 ceRNA 网络

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