在患有囊性纤维化症的新兴成年人中,在过渡期间进行内分泌护理:单一中心回顾性研究
Crystal Cobb1, Jenna Feeley2, José Nilo G Binongo3
1Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
概括
与囊性纤维化相关的糖尿病 (CFRD) 和骨病 (CFBD) 等内分泌并发症在过渡到成人囊性纤维化 (CF) 护理的新兴成年人中恶化. 在这个脆弱时期加强查至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 肺部病理学 肺部病理学
- 儿科 儿科 儿科
背景情况:
- 囊性纤维化 (CF) 通常表现为内分泌问题,包括囊性纤维化相关糖尿病 (CFRD) 和囊性纤维化相关骨病 (CFBD).
- 从儿科到成人护理的过渡是管理CF内分泌病变的关键时期,但这一阶段的趋势未得到充分研究.
研究的目的:
- 调查新兴CF成年人的血糖控制 (CFRD) 和骨密度 (CFBD) 的变化,直到10年过渡到成人护理后.
- 在这个过渡时期分析内分泌查率.
主要方法:
- 94名参与者 (年龄在18-30岁) 的回顾性图表审查过渡到成年CF护理.
- 骨矿物质密度 (BMD) 和维生素D状态的比较.
- 使用线性混合效应模型对血红蛋白A1c (HbA1c) 趋势的分析.
主要成果:
- 接受胰岛素治疗的患有CFRD的参与者在成人护理五年内显示出HbA1c显著增加 (7.8%至9.4%).
- 47%的新兴成年人至少有一个低BMDZ-score (<-1).
- 观察到口服葡萄糖耐受性测试 (OGTT) 和DXA查的完成率较低.
结论:
- 在CF患者的儿科到成人护理过渡期间,CFRD和CFBD的健康结果在CF患者的儿科到成人护理过渡期间恶化.
- 医疗保健提供者必须承认这一脆弱的过渡阶段,并实施加强的CFRD和CFBD查计划.
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