阿佩林-36通过KLF2/Occludin通路减轻糖尿病淋巴细胞内皮膜的过性
Jinxiao Jiang1, Liu Yang2, Yuhao Cheng3
1Department of Nephrology, Huanggang Central Hospital of Yangtze University, Huanggang, Hubei, 438000, China.
Peptides
|February 14, 2026
概括
阿佩林-36/APJ轴通过降低质内皮细胞的通透性来保护糖尿病病. 这一途径涉及KLF2和奥克卢丁,为糖尿病损伤提供了潜在的治疗标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 糖尿病脏病 (DN) 的特点是质内皮细胞 (GEC) 透性增加.
- 在DN中Apelin-36/APJ信号通路的作用仍然不完全理解.
研究的目的:
- 调查阿佩林-36/APJ轴在糖尿病疾病中的保护作用.
- 阐明质内皮细胞中潜在的分子机制.
主要方法:
- 在体外研究中,使用暴露于高葡萄糖 (HG) 的人类囊内皮细胞 (HRGEC) 进行了实验.
- 在体内研究使用db/db糖尿病病的小鼠模型.
- 评估APJ表达,阿佩林-36分泌,内皮通透性,奥克卢丁和克鲁佩尔样因子2 (KLF2) 水平.
主要成果:
- 在HRGEC中,高葡萄糖降低了APJ和Apelin-36,增加了透性.
- 阿佩林-36治疗减轻了超透性,恢复了KLF2和Occludin的表达,并激活了阿佩林/APJ系统.
- KLF2 敲除或 APJ 抑制否定了阿佩林-36 的保护作用.
- 在体内,Apelin-36降低了albuminuria,并恢复了db/db小鼠中的球性奥克卢丁.
结论:
- 阿佩林-36/APJ轴保护DN中的质内皮功能障碍.
- 这种保护通过KLF2/Occludin通路进行介导.
- 阿佩林-36/APJ轴代表了糖尿病损伤的潜在治疗标.
更多相关视频
06:39Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
6.1K
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
982
相关概念视频
Transcription Attenuation in Prokaryotes
18.6K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure. Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
18.6K
Glomerular Filtration
5.6K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
5.6K
Pathophysiology of Diabetes
3.7K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
C4 Pathway and CAM
49.4K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.4K
Glomerular Filtration Rate and its Regulation
5.6K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.6K
Glomerular Filtration: Net Filtration Pressure
8.5K
Glomerular filtration, a key process in the kidneys, is regulated by three main pressures: Glomerular blood hydrostatic pressure (GBHP), Capsular hydrostatic pressure (CHP), and Blood colloid osmotic pressure (BCOP).
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
8.5K
