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Bernoulli's Equation for Flow Normal to a Streamline01:16

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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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在高流量和低流量正常带状网状细胞中的流量依赖引.

Alireza Karimi1, Hasti Golchin1, Ansel Stanik2

  • 1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States.

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概括

高流动的脊柱状网状组织/直通管状组织 (TM/JCT) 细胞感知剪切流动,增加收缩和旋转力. 低流量TM/JCT细胞对剪切不敏感,这可能解释了青光眼中增加的外流阻力.

关键词:
原蛋白是一种原蛋白.眼光障碍 眼光障碍 眼光障碍 眼光障碍聚烯胺的使用方法剪切流动 剪切流动拉力力显微镜 拉力力显微镜

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科学领域:

  • 生物力学 生物力学
  • 细胞生物学 细胞生物学
  • 眼科医生 眼科 眼科

背景情况:

  • 水性幽默流出通道的高流量 (HF) 区域是合规的,而低流量 (LF) 区域是刚硬的,不敏感于剪切.
  • 玻璃眼,以增加的眼内压力为特征,与液体排水的轨道眼网状组织的硬化有关.
  • 了解剪切流是如何影响细胞矩阵生物力学,在不同区域的尾状网状网络对于眼研究至关重要.

研究的目的:

  • 为了研究人类脊椎状网状网络/直径管状组织 (TM/JCT) 细胞如何将剪切流转化为细胞矩阵生物力学的区域差异.
  • 为了确定HF和LFTM/JCT细胞是否对剪切应激表现出不同的反应,可能揭示着青光眼病原体的发病机制.

主要方法:

  • 来自单个捐赠者的人类HF和LFTM/JCT细胞在原涂层的多烯胺凝上培养.
  • 用嵌入FluoSpheres的3D引力显微镜来测量细胞矩阵力.
  • 一个循环系统应用控制的剪流 (无流 → 流和流 → 无流) 每个6小时,与计算流体动力学校准.

主要成果:

  • HFTM/JCT细胞在剪切流下表现出增加的引力和卷曲,表明"收缩-卷曲"的特征.
  • 长肌/JCT细胞显示出相对不敏感的剪切反应,通过形剪切合保持持续的张力.
  • 在12小时的流量后,HF细胞表现出比LF细胞更高的引和卷曲,HF分歧仍然为负 (收缩),而LF分歧保持在接近零/正的水平.

结论:

  • HFTM/JCT细胞充当可逆剪切传感器,调节剪切流的收缩性和旋转力.
  • 肺结核TM/JCT细胞保持持续紧张状态,剪切反应能力降低,有助于矩阵紧缩.
  • 在LF区域,这种特定区域的剪切感应损失可能会增加外流阻力,并导致青光眼的进展.