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莫莫迪卡·查兰蒂亚的抗菌原潜力,植物化学和分子对接分析:一个体外研究

Syed Nahid Basheer¹, Arwa Daghrery¹, Nassreen Albar¹

¹Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan, 82914, Kingdom of Saudi Arabia.

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|February 14, 2026

概括

野生苦瓜 (Momordica charantia) 提取物显示出对抗牙病原体的潜力. 这种天然疗法有效地抑制了细菌生长和生物膜的形成,为口腔健康管理提供了有前途的替代方案.

科学领域:

自然产品化学化学
微生物学微生物学
口腔健康研究研究口腔健康研究

背景情况:

牙损伤是一种普遍的口腔疾病,由菌性细菌引起,如Streptococcus mutans和Lactobacillus acidophilus.
抗微生物耐药性的增加需要探索治疗口腔病原体的天然替代品.

研究的目的:

评估野生苦瓜 (Momordica charantia) 乙醇提取物的抗菌和抗生物膜活性,以对抗空白致病细菌.
为了识别提取物中的生物活性化合物,并预测它们与细菌毒性因子的相互作用.

主要方法:

索克斯莱特提取物用于制备M. charantia乙醇提取物.
在GC-MS分析中确定了关键的生物活性化合物.
通过扩散,MIC和MBC测定来评估抗菌活性. 通过MBEC和生物膜抑制/破坏试验来确定抗生物膜活性. 分子对接预测了Charantadiol A和细菌蛋白之间的相互作用.

主要成果:

查兰蒂亚菌的提取物具有显著的抗菌活性,抑制区 (14-18毫米) 和MIC值为300μg/mL.
提取物在MIC以下度下有效抑制生物膜的形成.
分子对接表明Charantadiol A与S. mutans (comA) 和L. acidophilus (luxS) 蛋白质具有有利的结合能量.

结论:

莫莫迪卡·查兰蒂亚 (Momordica charantia) 乙醇提取物显示出有前途的抗焦化物和抗生物膜潜力.
这些发现支持进一步的体内和临床研究,用于其在口腔健康管理中的应用.

关键词:

牙科生物膜是一种牙科生物膜.牙腐烂是指牙的腐烂.莫莫迪卡 (Momordica charantia) 是一个的动物.植物化学品植物化学品 Streptococcus mutans 和 Lactobacillus acidophilus 这两种细菌都存在.野生苦瓜野生苦瓜

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