多功能生物传感器重新定义了液体活检:推进了同时多分析检测.
Panagiota M Kalligosfyri1, Antonella Miglione1, Ada Raucci1
1Department of Pharmacy, University of Naples 'Federico II', Naples 80131, Italy.
Trends in biotechnology
|February 14, 2026
概括
多功能生物传感器通过同时检测多个生物标志物来推进液体活检. 这改善了疾病的诊断和监测,为精准医学和早期检测铺平了道路.
科学领域:
- 生物医学工程 生物医学工程
- 分子诊断学 分子诊断学
- 纳米技术纳米技术
背景情况:
- 液体活检可以通过检测循环中的生物标志物来实现非侵入性疾病诊断.
- 目前的单分析方法缺乏捕获复杂疾病的灵敏度.
- 多功能生物传感器为全面的液体活检分析提供了一种新方法.
研究的目的:
- 审查用于液体活检的多功能生物传感器的最新进展.
- 探索创新的检测策略和整合技术.
- 讨论临床翻译的挑战和未来方向.
主要方法:
- 综述各种检测策略:光学,电化学,等离子体,基于CRISPR的测试.
- 混合平台,表面工程和纳米技术的探索.
- 讨论与微流体学,人工智能和化学分析的整合.
主要成果:
- 多功能生物传感器可以同时检测多个生物标志物.
- 创新提高了灵敏度,减少干扰,提高了可扩展性.
- 与人工智能和微流体等先进技术的整合至关重要.
结论:
- 多功能生物传感器代表了液体活检的范式转变.
- 这些生物传感器在精准医学和早期疾病检测方面具有变革性的潜力.
- 解决临床翻译和标准化方面的挑战是广泛采用的关键.
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