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Updated: Feb 16, 2026

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通过调节微管子动态,FOXJ1调节了对标杆菌的抗性

Fang Xie1, Ada Gjyrezi2, Daniel Fein1

  • 1Department of Medicine, Division of Oncology and Cancer Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Nature communications
|February 14, 2026
PubMed
概括

通过改变微管的动态,FOXJ1基因表达驱动前列腺癌 (PC) 中的多塞塔塞尔耐药性. 准这种FOXJ1通路可能有助于识别不太可能从纳税化疗中受益的患者.

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Microtubules

There are three types of cytoskeletal structures in eukaryotic cells—microfilaments, intermediate filaments, and microtubules. With a diameter of about 25 nm, microtubules are the thickest of these fibers. Microtubules carry out a variety of functions that include cell structure and support, transport of organelles, cell motility (movement), and the separation of chromosomes during cell division.
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Microtubules are the thickest cytoskeletal filaments with a diameter of 25 nm. In prokaryotic organisms, microtubules are commonly found in locomotory appendages like cilia and flagella. In eukaryotic cells, microtubules form specialized extensions for moving fluid over the surface, like those found in cells lining the intestine.
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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as microtubule organizing centers or MTOCs. Within the MTOC, the point of origin of the microtubule is known as the minus end, while the end radiating outward is the plus end. Microtubules serve two primary functions — the organization of spindle complexes to separate sister chromatids during mitotic or meiotic cell division and the formation...
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