祖先的神经受体是细菌的辅助毒素
Finaritra Raoelijaona1,2, Joanna Szczepaniak1, Adrien Schahl3
1Department of Biochemistry, University of Oxford, Oxford, UK.
Nature communications
|February 14, 2026
概括
对于神经元发育至关重要的metazoan Teneurins,起源于细菌毒素. 这项研究揭示了它们的进化联系,表明重新利用的细菌毒素成为复杂神经系统中细胞间通信的关键.
科学领域:
- 进化生物学 进化生物学
- 分子生物学分子生物学
- 神经科学是一个神经科学.
背景情况:
- 水平基因转移 (HGT) 显著影响了复杂生命的进化.
- 黑色素是元动物神经元发育中的关键细胞粘附受体.
- 甲动物色素的细菌起源以前尚不清楚.
研究的目的:
- 为了阐明细菌和甲动物 Teneurins之间的进化关系.
- 为了研究细菌色素的结构和功能.
- 为了证实metazoan Teneurins是重新使用的细菌毒素的假设.
主要方法:
- 低温电子显微镜 (cryo-EM) 用于确定细菌色素的结构.
- 生物信息学分析被用来追踪进化关系.
- 进行了比较基因组学和遗传学分析.
主要成果:
- 细菌黑色素具有一个有毒的蛋白质,被封闭在一个蛋白质的外中.
- 这些细菌色素很少见,但在各种细菌种群中广泛分布.
- 细菌色素在表现出复杂社会行为的物种中更为普遍,这表明它们在细胞与细胞相互作用中的作用.
结论:
- 甲动物的黑色素确实是重新利用的细菌毒素.
- 这些细菌毒素的获取是元动物进化中的一个关键事件.
- 黑色素已经从细菌毒素演变为高级神经系统中细胞间通信的重要媒介.
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