芯片上的女性生殖道用于选择具有超低DNA碎片化指数的精子
Jing Dai1,2, Han Shan3,4,5, Yifan Gu6,7
1NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China. daijing2021@csu.edu.cn.
Microsystems & nanoengineering
|February 14, 2026
概括
选择具有低DNA碎片化指数 (DFI) 的精子对于男性不孕症至关重要. 一种新的女性生殖管芯片 (FRToC) 装置成功地隔离了超低DFI的精子,改进了辅助生殖技术 (ART).
科学领域:
- 生殖生物学 生殖生物学
- 生物医学工程 生物医学工程
- 遗传学 遗传学 是一个
背景情况:
- 高精子DNA碎片化指数 (DFI) 是男性不孕症的一个重要原因.
- DFI对胚胎发育和后代健康产生负面影响.
- 目前用于选择低DFI精子的方法具有挑战性.
研究的目的:
- 开发一种器官级别的选择策略,以隔离具有超低DFI的精子.
- 创建和验证一个女性生殖系统芯片 (FRToC) 设备,用于体内类似的精子选择.
- 评估FRToC选择精子的质量,包括运动性,完整性和染色体稳定性.
主要方法:
- 制造一个模拟生理微环境的女性生殖管芯片 (FRToC) 设备.
- 临床验证使用不同DFI水平的患者精液样本.
- 分析精子质量 (DFI,运动性,体完整性),蛋白质组学和单细胞复制数变异 (CNV).
主要成果:
- 该FRToC装置实现了显著的DFI降低,从原始精液中的平均41.93%降至精子中的0.71%.
- 与原始精子相比,精子具有更高的运动性和体完整性.
- 用FRToC进行排序的精子显示出增强缓解氧化应激和保持染色体完整性的能力.
结论:
- 该FRToC装置提供了一个有效的器官级策略,用于选择具有超低DFI的高质量精子.
- 这项技术对改善辅助生殖技术 (ART) 的结果具有重大前景.
- 该方法为与高精子DNA碎片化相关的男性不孕症提供了潜在的解决方案.
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